Endoscopic therapy of esophageal and gastric varices

Acute gastric variceal bleeding is a serious complication that occurs in patients with portal hypertension. Left untreated, bleeding gastric varices carry a risk of mortality of up to 45%.

Both the American Association for the Study of Liver Disease (AASLD) and European Association for the Study of the Liver (EASL) recommend that this acute condition is treated by the injection of cyanoacrylate adhesive into the varix, despite there being no adhesives approved for this use in the USA.

Cyanoacrylate adhesives are complex to use. Prior to administration, current cyanoacrylates require time-consuming, multi-step preparation. This is challenging in an emergency situation where fatalities are common in the absence of timely intervention.

GastrovarTM  is a new device, developed by Limmedx, for treating bleeding gastric varices. GastrovarTM overcomes the technical challenges of cyanoacrylate adhesive administration in this acute and life-threatening area of high medical need.

 

Device for bleeding gastric varices: development timeline